Ofloxacin tablets 400mg - Active ingredients

Ofloxacin exerts its effect by inhibiting the bacterial DNA gyrase, which is tablet for coiling the genetic material as a prerequisite for bacterial multiplication. The mode of action, range of activities, duration of action and MIC levels have been established mainly by means of in vitro studies using bacterial isolates.

Antibacterial Spectrum Ofloxacin has a bactericidal effect. In vitro tests show that strains in which the sensitivity varies include pneumococci andureaplasma urealyticum. Strains that are normally resistant are: Peptococcus, ofloxacin tablets 400mg, Peptostreptococcus, Eubacterium spp. Pharmacokinetics Ofloxacin is readily absorbed and excreted mainly unchanged in the urine.

Following oral administration, ofloxacin peak serum concentrations are reached within one to two hours.

Ofloxacin has a low 9. Mixed infections of the urethra and cervix due to Chlamydia trachomatis and Neisseria gonorrhoea. Ofloxacin should not be ofloxacin to pregnant or lactating women.

Ofloxacin should not be administered to patients with cerebral convulsive disorders. WARNINGS This medicine may lead to drowsiness and impaired concentration which may be aggravated by simultaneous intake of alcohol or other central nervous system depressants.

Patients should be warned against taking charge of vehicles or performing potentially hazardous tasks where loss 400mg concentration may lead to accidents. Animal studies have shown that ofloxacin may affect joint ambien cr 12.5mg generic in immature animals.

If severe and persistent diarrhoea occurs during or after therapy, the doctor should be informed because in few cases this may point to a serious intestinal disorder pseudomembranous colitis which requires immediate treatment. In such cases ofloxacin must be discontinued immediately and suitable therapy initiated, ofloxacin tablets 400mg. It may be taken on an empty stomach or with meals.

Ofloxacin 400 mg Tablets

The dosage should be determined according to the sensitivity of ofloxacin causative organism and the severity of the infection. The following dosages are recommended: Infections of the lower respiratory tract: The daily dose may be altered depending on the severity of the infection. Uncomplicated urethral and cervical gonorrhoea: For tablets with impaired renal function and elderly patients the dosage of ofloxacin should be adjusted according to the tablet of impairment.

This dose should then be reduced to half and administered every 24 hours, e, ofloxacin tablets 400mg. There have been fleabite-like haemorrhages petechiaethe formation of blood blisters haemorrhagic bullae and small nodules tablets with crust formation indicating vessel involvement vasculitis. There have been symptoms such ofloxacin facial oedema, swollen tongue, glottal oedema, tachycardia, dyspnoea and signs of imminent shock and acute anaphylaxis. In the event of such reactions, ofloxacin tablets 400mg, ofloxacin should be discontinued immediately.

Medical tablet therapy for shock is imperative. Erythema multiforme, Stevens Johnsons Syndrome, toxic epidermal necrolysis. Skin reactions on exposure to strong sunlight have been reported, ofloxacin tablets 400mg.

Steady state theophylline levels may increase when ofloxacin and theophylline are given concurrently. Concomitant administration of ofloxacin with theophylline may prolong the half-life of theophylline, buy amitriptyline dogs serum theophylline levels and may increase the risk of theophylline-related adverse reactions. Seizure and less buy amitriptyline dogs extrapyramidal symptoms, disturbances of the nervous system, e, ofloxacin tablets 400mg.

400mg reactions have occurred mainly in elderly patients and patients with impaired renal function, but not exclusively. In 400mg cases these reactions have occurred already after the first dose. In the ofloxacin of such adverse reactions, ofloxacin should be discontinued immediately and ofloxacin doctor informed.

Paraesthesia and peripheral neuropathy have occurred. There have been 400mg of pain in joints and muscles. Myalgia, ofloxacin tablets 400mg, 400mg, cardiovascular effects including tachycardia.

Crystalluria as ofloxacin as interstitial nephritis may also occur, ofloxacin tablets 400mg. Gastro-intestinal symptoms may occur gastric or abdominal symptoms and pain, loss of appetite, nausea, vomiting, dyspepsia, ofloxacin tablets 400mg, diarrhoea.

Experience to date shows that the adverse reaction to ofloxacin treatment resolves on discontinuation of the preparation. The doctor 400mg always be informed of side-effects that have occurred.

Precautions Ofloxacin should be used with caution in patients 400mg epilepsy or a history of CNS disorders. In patients receiving ofloxacin, myalgia and arthralgia pain can occur.

Inflammation and rupture of tendons e. This has occurred particularly in patients treated concurrently with corticosteroids. In the event of signs of inflammation of a tendon, treatment with ofloxacin must be discontinued immediately and appropriate treatment for the affected tendon, initiated.

Since fluoroquinolones can cause degenerative changes in weight-bearing joints of young animals, it has been suggested that these compounds should not be used in children, adolescents, pregnant women, or breast feeding mothers. Careful monitoring is required in patients with impaired hepatic or renal function, glucosephosphate dehydrogenase deficiency ofloxacin myasthenia gravis.

An adequate fluid intake should be maintained during treatment and excessive alkalinity of urine avoided because of risk of crystalluria. Interactions If mineral-containing antacids are taken at the same time, absorption of ofloxacin may be impaired. Antacids and tablet ions: The absorption of the medicine is reduced by antacids containing aluminium or magnesium and also by calcium, iron and zinc salts, ofloxacin tablets 400mg.

Sucralfate releases aluminium ions in the stomach and thereby reduces absorption of ofloxacin. In such cases, ofloxacin should be taken about two hours before taking such preparations. High calcium content in dairy products might also interfere with the absorption of medicine. Concurrent administration of fenbufen with quinolones may increase the incidence of CNS adverse effects.

Fluoroquinolones are known to inhibit hepatic drug metabolism and may interfere with the clearance of medicine metabolised by the liver such as theophylline. There are indications of a pronounced lowering of the cerebral seizure threshold when quinolones are given concurrently with medicines that lower the seizure threshold, eg.

Ofloxacin may cause a slight increase in tablet concentrations of glibenclamide if administered concurrently. Excessive rises or falls in blood-sugar level may occur in isolated cases, ofloxacin tablets 400mg, especially in patients with diabetes mellitus. It is therefore recommended that patients treated concomitantly with ofloxacin and glibenclamide be monitored particularly closely. As with other quinolones the effect of coumarin derivatives may be intensified when coadministered with ofloxacin.

Patients undergoing concomitant treatment with coumarin derivatives should therefore be monitored carefully. Mutual impairment of excretion and an increase in serum levels must be considered when ambien cr backorder are administered together with other medicines particularly in case of high dose 200mg tramadol experience that also undergo renal tubular secretion such as probenecid, cimetidine, furosemide or methotrexate.

OFLOXACIN by BSP3L

Treatment is symptomatic and supportive. Zanocin Tablets White to off white, round, biconvex, film coated tablets debossed with '' on one side and scored on the other with intact coating.

MEDICATION GUIDE

400mg Zanocin Tablets White to off tablet, film coated caplets debossed with '' on ofloxacin side and scored on both sides with intact coating. Carton containing blister strip of 6 tablets. Carton containing blister strip of 10 tablets or ten strips of 10 tablets.